Charting a Path Toward New Treatments for Lyme Infection-Associated Chronic IllnessesAround 10-20% of people who contract Lyme disease, the most common tickborne disease in the U.S., develop persistent, often debilitating symptoms such as chronic pain, fatigue, and cognitive dysfunction. Lyme infection-associated chronic illnesses (I May 09 25May 09, 2025Article at NASEM
Whole-Person Oral Health Education: Proceedings of a WorkshopIn February 2024, the National Academies Global Forum on Innovation in Health Professional Education co-hosted a public workshop with Penn Dental Medicine to explore value proposition for oral health promotion and disease prevention. Experts from aro May 09 25May 09, 2025Article at NASEM
The role of quality of life data as an endpoint for collecting real-world evidence within geroscience clinical trialsCollecting real-world evidence (RWE) may accelerate validation of gero-interventions.Quality of life (QoL) assays evaluate aspects… Jun 04 24June 04, 2024Article at Maartje on Authory
Impact and Control of Valley FeverNational Academies of Sciences, Engineering, and Medicine. 2023. Impact and Control of Valley Fever: Proceedings of a Workshop–in Brief. Washington, DC: The National Academies Press. https://doi.org/10.17226/26928. Import this citation to: Bibtex… May 01 23May 01, 2023Article at NASEM
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapyGo to: Abstract CD103+ tumor-infiltrating lymphocytes (TIL) have been linked to specific epithelial infiltration and a prolonged survival in high-grade serous epithelial ovarian cancer (HGSC). However, whether these cells are induced as part of an… Nov 15 22November 15, 2022Article at OncoTarget
Vaccine Research and Development to Advance Pandemic and Seasonal Influenza Preparedness and ResponseThe global response to COVID-19 has demonstrated the importance of vigilance and preparedness for infectious diseases, particularly influenza. There is a need for more effective influenza vaccines and modern manufacturing technologies that are… Jan 28 22January 28, 2022Article at NASEM
Single-cell Profiles and Prognostic Impact of Tumor-Infiltrating Lymphocytes Coexpressing CD39, CD103, and PD-1 in Ovarian CancerAbstract Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly defined. CD39, CD103, and PD-1 have been independently… Jul 15 21July 15, 2021Article at Clinical Cancer Research
Co-expression patterns of chimeric antigen receptor (CAR)-T cell target antigens in primary and recurrent ovarian cancerHighlights •CA125, mesothelin and folate receptor alpha showed patchy and partially overlapping expression patterns in ovarian cancer.•An OR-gated CAR strategy against CA125 and mesothelin would target over 90% of tumor cells in over half of… Feb 02 21February 02, 2021Article at Gynecologic Oncology
The immune suppressive factors CD155 and PD-L1 show contrasting expression patterns and immune correlates in ovarian and other cancersHighlights •Members of the CD155/TIGIT immune checkpoint pathway are commonly expressed in HGSC and other cancers.•In HGSC, expression of CD155 and TIGIT is substantially more frequent than expression of PD-L1 and PD-1.•In contrast to PD-L1, CD155 is… Jul 01 20July 01, 2020Article at Gynecologic Oncology
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcomeIn this article Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited curative therapeutic options. Immunotherapy for EOC is promising, but clinical efficacy remains restricted to a small percentage of patients.… Jul 25 19July 25, 2019Article at OncoImmunology
A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human CancerAbstract The chemokine CXCL13 mediates recruitment of B cells to tumors and is essential for the formation of tertiary lymphoid structures (TLSs). TLSs are thought to support antitumor immunity and are associated with improved prognosis. However, it… May 01 19May 01, 2019Article at Clinical Cancer Research
Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human CancerAbstract There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells (PC) remains controversial, leading to differing opinions… Dec 13 18December 13, 2018Article at Clinical Cancer Research
Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian CancerAbstract Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dramatic and durable response to treatment. We sought to identify clinical, pathological, and molecular… Jan 31 18January 31, 2018Article at Clinical Cancer Research
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinomaIntroduction Endometrial cancer (EC) is the most common gynaecologic malignancy worldwide and the fourth most common malignancy afflicting women in developed countries [1]. Although the vast majority of patients are diagnosed in early stages, a… Jun 09 16June 09, 2016Article at Gynecologic Oncology
Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian CancerAbstract Purpose: Tumor-infiltrating lymphocytes (TIL) are associated with a better prognosis in high-grade serous ovarian cancer (HGSC). However, it is largely unknown how this prognostic benefit of TIL relates to current standard treatment of… Jan 31 16January 31, 2016Article at Clinical Cancer Research
