Around 10-20% of people who contract Lyme disease, the most common tickborne disease in the U.S., develop persistent, often debilitating symptoms such as chronic pain, fatigue, and cognitive dysfunction. Lyme infection-associated chronic illnesses (I

In February 2024, the National Academies Global Forum on Innovation in Health Professional Education co-hosted a public workshop with Penn Dental Medicine to explore value proposition for oral health promotion and disease prevention. Experts from aro

Collecting real-world evidence (RWE) may accelerate validation of gero-interventions.Quality of life (QoL) assays evaluate aspects…

National Academies of Sciences, Engineering, and Medicine. 2023. Impact and Control of Valley Fever: Proceedings of a Workshop–in Brief. Washington, DC: The National Academies Press. https://doi.org/10.17226/26928. Import this citation to: Bibtex…

Go to: Abstract CD103+ tumor-infiltrating lymphocytes (TIL) have been linked to specific epithelial infiltration and a prolonged survival in high-grade serous epithelial ovarian cancer (HGSC). However, whether these cells are induced as part of an…

The global response to COVID-19 has demonstrated the importance of vigilance and preparedness for infectious diseases, particularly influenza. There is a need for more effective influenza vaccines and modern manufacturing technologies that are…

Abstract Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly defined. CD39, CD103, and PD-1 have been independently…

Highlights •CA125, mesothelin and folate receptor alpha showed patchy and partially overlapping expression patterns in ovarian cancer.•An OR-gated CAR strategy against CA125 and mesothelin would target over 90% of tumor cells in over half of…

Highlights •Members of the CD155/TIGIT immune checkpoint pathway are commonly expressed in HGSC and other cancers.•In HGSC, expression of CD155 and TIGIT is substantially more frequent than expression of PD-L1 and PD-1.•In contrast to PD-L1, CD155 is…

In this article Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited curative therapeutic options. Immunotherapy for EOC is promising, but clinical efficacy remains restricted to a small percentage of patients.…

Abstract The chemokine CXCL13 mediates recruitment of B cells to tumors and is essential for the formation of tertiary lymphoid structures (TLSs). TLSs are thought to support antitumor immunity and are associated with improved prognosis. However, it…

Abstract There is abundant evidence that tumor-infiltrating CD8+ T cells contribute positively to antitumor immunity; however, the role of tumor-infiltrating B cells (TIL-B) and plasma cells (PC) remains controversial, leading to differing opinions…

Abstract Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dramatic and durable response to treatment. We sought to identify clinical, pathological, and molecular…

Introduction Endometrial cancer (EC) is the most common gynaecologic malignancy worldwide and the fourth most common malignancy afflicting women in developed countries [1]. Although the vast majority of patients are diagnosed in early stages, a…

Abstract Purpose: Tumor-infiltrating lymphocytes (TIL) are associated with a better prognosis in high-grade serous ovarian cancer (HGSC). However, it is largely unknown how this prognostic benefit of TIL relates to current standard treatment of…