Rice-BCM research achieves gene-editing breakthrough that could improve treatment for liver disease, other disordersThe Rice lab of bioengineer Gang Bao and collaborators at Baylor College of Medicine have developed a new gene-editing strategy that dramatically boosts the effectiveness of gene therapies in the liver, a breakthrough that could lead to new Feb 13 25February 13, 2025Article at news.rice.edu
Major breakthrough for ‘smart cell’ designRice bioengineers have developed a new construction kit for building custom sense-and-respond circuits in human cells. The research is a major breakthrough that could revolutionize therapies for complex conditions like autoimmune disease and cancer. Jan 03 25January 03, 2025Article at news.rice.edu
Rice bioengineers shed light on dosing challenges for cancer immunotherapyA team of Rice bioengineers has developed a mathematical model that clarifies why interleukin-12 ⎯ a potent immune-boosting protein that holds promise for cancer treatment ⎯ loses effectiveness over time when used as an immunotherapeutic. Nov 06 24November 06, 2024Article at news.rice.edu
Rice bioengineers awarded $3.4M for project to end polioRice bioengineer Kevin McHugh has been awarded $3.4 million for a project to incorporate protection against polio into the combination vaccine that protects against five common and dangerous childhood diseases. Oct 09 24October 09, 2024Article at news.rice.edu
Molecular jackhammers’ ‘good vibrations’ eradicate cancer cellsRice scientists and collaborators at Texas A&M University and University of Texas MD Anderson Cancer Center have found a new way to kill cancer cells by using near-infrared light to make a small dye molecule attached to their membrane vibrate Dec 19 23December 19, 2023Article at news.rice.edu
DREAM tool for gene therapies uses ‘locally sourced’ componentsRice bioengineers developed a tool that activates silent or insufficiently expressed genes using human-derived building blocks and a CRISPR-based genome-targeting platform. Oct 09 23October 09, 2023Article at news.rice.edu
Tiny CRISPR tool could help shred virusesRice scientists mapped out the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems then used that knowledge to modify its structure and improve its accuracy. Sep 27 23September 27, 2023Article at news.rice.edu
Split gene-editing tool offers greater precisionTo make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third molecule is added. Sep 21 23September 21, 2023Article at news.rice.edu
Protective particles allow engineered probiotics to report gut diseaseRice U. bioengineers developed a platform that enhances survival and function of probiotics engineered to diagnose inflammatory bowel disease in animals. The technology holds promise for minimally invasive disease monitoring and advanced smart Aug 16 23August 16, 2023Article at news.rice.edu
NIH grant backs Rice lab’s sickle cell disease researchRice University bioengineer Gang Bao and his team have won a grant from the National Institutes of Health to address critical questions surrounding the safety and efficacy of using gene editing to treat sickle cell disease. Jul 18 23July 18, 2023Article at news.rice.edu
Rice chemist wins $3.2M National Cancer Institute grantRice University chemist Han Xiao has won a $3.2 million research project (R01) grant from the National Cancer Institute to develop the first tissue-specific epigenetic inhibitor drug to treat bone metastasis. Jul 17 23July 17, 2023Article at news.rice.edu
Cellular process that fuels plant growth yields surprising insightsA new study by Rice University bioscientists explains how structures inside plant cells collaborate to fuel germination. The findings could shed light on corresponding mechanisms in human cells. Jul 12 23July 12, 2023Article at news.rice.edu
Light-activated molecular machines get cells ‘talking’Rice University scientists have used light-activated molecular machines to induce cell-to-cell calcium signaling, revealing a powerful new strategy for drug design. This technology could lead to improved treatments for people with heart problems, Jul 10 23July 10, 2023Article at news.rice.edu
New enzyme could aid anticancer drug developmentRetracing nature’s steps, Rice University engineer Xue Gao and her team mapped out the full series of enzyme-powered reactions a marine fungus uses to produce a complex molecule with anticancer properties. In the process, the Gao lab uncovered the Jun 27 23June 27, 2023Article at news.rice.edu
Rice U. chemist leverages heterogeneity for insight into catalysis, cancer initiationRice U. chemist Anatoly Kolomeisky has won a National Science Foundation award to study the role of heterogeneity in chemical and biological processes. Jun 15 23June 15, 2023Article at news.rice.edu
Experimental model gets cells to behave as they would in uteroRice U.’s Aryeh Warmflash wins $1.9 million NIH grant to develop experimental cell models that can shed light on critical embryonic developmental processes. May 08 23May 08, 2023Article at news.rice.edu
Study unlocks potential breakthrough in Type 1 diabetes treatmentRice University scientists identified three biomaterial formulations that could help develop a more sustainable, long-term, self-regulating way to treat Type 1 diabetes using a new screening technique that involves tagging each biomaterial Apr 27 23April 27, 2023Article at news.rice.edu
Upgraded tumor model optimizes search for cancer therapiesRice U. bioengineers have developed an upgraded tumor model that houses bone cancer cells beside immune cells inside a 3D structure engineered to mimic bone and, through research using the model, found that the body’s immune response can make tumor Mar 20 23March 20, 2023Article at news.rice.edu
Fats help tag medical implants as friend or foeRice University bioengineer Omid Veiseh and collaborators found that lipid deposition on the surfaces of medical implants can play a mediating role between the body and implants, knowledge that could help scientists develop biomaterials or coatings Mar 14 23March 14, 2023Article at news.rice.edu
Rice scientists reengineer cancer drugs to be more versatileRice University scientists enlist widely used cancer therapy systems to control gene expression in mammalian cells, a feat of synthetic biology that could change how diseases are treated. Feb 14 23February 14, 2023Article at news.rice.edu