In a Healio video exclusive, Edward V. Loftus Jr., MD, discusses lingering questions on the potential risks that gender-affirming hormone therapy may have for transgender patients with inflammatory bowel disease.

Use of GLP-1s was associated with significantly reduced risk for hepatic complications among patients with metabolic dysfunction-associated steatotic liver disease and type 2 diabetes, according to data.The observational study, published in The American Journal of Gastroenterology, showed that the reduction was prompted by fewer cases of incident cirrhosis. Researchers also found that GLP-1s may

Healio’s ninth annual Disruptive Innovators Awards for gastroenterology and hepatology will be presented this fall, honoring the pioneers whose groundbreaking work and bold ideas have redefined the field. Awardees will be recognized during a prestigious awards ceremony at the ACG Annual Meeting, scheduled for October 9-14 in Nashville.

CHICAGO — Combining golimumab and guselkumab into JNJ-78934804, a fixed-dose co-antibody therapy, helped overcome treatment failure in inflammatory bowel disease and exceeded dose-dependent benefits of either drug alone, according to data.Two parallel phase 2b trials combining the anti-tumor necrosis factor and anti-interleukin-23 medications in Crohn’s disease and ulcerative colitis,

CHICAGO — Insulin resistance markers and BMI were more effective in detecting steatotic liver disease among adolescents and young adults compared with glycemic and lipid measurements, according to study results. The data, presented at Digestive Disease Week, showed that BMI, estimated glucose disposal rate (eGDR) and homeostatic model assessment of insulin resistance (HOMA-IR) were

CHICAGO — Even with biologics changing the treatment paradigm for ulcerative colitis more than 2 decades ago, patients have a similar risk for undergoing colectomy a decade after diagnosis as they have had for the last 5 decades.The findings were presented at Digestive Disease Week.

CHICAGO — When comparing inflammatory bowel disease mortality from before the pandemic with during, the gap between related deaths among Black and white patients continued to expand across Southern and Midwestern states, a study found.The findings were presented at Digestive Disease Week.

The oral Janus kinase inhibitor upadacitinib was well tolerated for moderate to severe inflammatory bowel disease over a median 58 weeks, according to a study published in Clinical Gastroenterology and Hepatology.Using pooled data from six ulcerative colitis and Crohn’s disease trials, researchers assessed the long-term safety profile of upadacitinib (Rinvoq, AbbVie) at different doses vs.

Episodic heavy drinking is prevalent among individuals with metabolic dysfunction-associated steatotic liver disease and increases risk for advanced liver fibrosis, according to a study in Clinical Gastroenterology and Hepatology. If these heavy episodic drinkers were reclassified as having metabolic and alcohol-associated liver disease (MetALD), rather than MASLD, it would more than double the

Women who have two or more cardiometabolic risk factors were linked to a higher likelihood of significant liver fibrosis compared to men with the same risk factors, according to cross-sectional study results.The study, published in JAMA Network Open, also showed that high waist circumference, prediabetes and type 2 diabetes were associated with higher odds of clinically significant liver fibrosis

Medications for alcohol use disorder were associated with improved survival among patients who had severe alcohol-related liver disease and were being evaluated for a liver transplant, according to a study published in JAMA Network Open.Even though alcohol-related liver disease (ALD) is a leading indicator for needing a liver transplant in the U.S., medications to treat alcohol use disorder (AUD)

The American Association for the Study of Liver Diseases supports a court ruling that temporarily blocks changing the childhood and adolescent immunization schedule, including the hepatitis B birth and childhood hepatitis A vaccinations.The ruling, made by U.S. District Judge Brian E. Murphy on March 16, halted the Trump administration’s modifications to the CDC’s evidence-based

Finding ways that AI best fits into clinical practice while learning how accurate and useful it can be, especially for patients, could help clinicians trust it more in their daily workflow.“I do think that AI in health care has a long way to go to be trusted by most of us,” James Barry, MD, MBA, neonatologist and professor of pediatrics-neonatology and medical director at University

Ethosuximide, a T-type calcium channel blocker, demonstrated no significant benefit as a treatment for patients with irritable bowel syndrome-related abdominal pain, according to results of a proof-of-concept clinical trial.

LAS VEGAS — GLP-1 receptor agonists offer more than weight loss for patients with inflammatory bowel disease, with markedly improved outcomes indicating anti-inflammatory benefit, according to data presented at Crohn’s & Colitis Congress.

LAS VEGAS — For patients with acute severe ulcerative colitis treated in tertiary care, accelerated infliximab induction significantly reduced odds of a colectomy at 2 years, according to data presented at Crohn’s & Colitis Congress.However, the lower odds of needing a colectomy in the short term were not significant, which could indicate that the severity of inflammatory bowel

LAS VEGAS — LGBTQ+ individuals with inflammatory bowel disease experience multiple gaps and inequities in care when managing their condition, study results showed. Among the most reported were negative clinical encounters, delays in diagnosis, insurance barriers, ineffective initial treatments and discrimination.

The American Association for the Study of Liver Diseases has raised concerns that federal health agencies have dropped alcohol limits from the latest dietary guidelines and failed to include the established link between alcohol and cancer.On Jan. 7, HHS and the U.S. Department of Agriculture released the 2025-2030 Dietary Guidelines for Americans (DGA), which recommend that Americans’ diet