Zai Lab bombs Phase IIa trial in atopic dermatitis, junks the program to shift resources to the pipelineNasdaq darling and Shanghai hotshot Zai Lab is ditching one of its late-stage drug programs after bombing a Phase IIa trial. The company said Friday that its topical product ZL ... Aug 24 18August 24, 2018Article at endpoints.news
A new avenue for diet pill makers? UC San Diego researchers uncover root of leptin resistanceLet’s be honest, the market for weight loss drugs has mostly been bust. While the industry has moved on from the fen-phen fiasco of decades past, newer diet pills like ... Aug 23 18August 23, 2018Article at endpoints.news
Once lauded for its clinical success, Roche casts off cardio program inclacumab for a mere $2M to Global Blood TherapeuticsFive years ago, Roche touted a clinical success for one of its mid-stage cardio programs, reporting the investigational med showed promise in reducing heart damage. Promising, they said, but apparently ... Aug 23 18August 23, 2018Article at endpoints.news
Magic mushrooms might treat depression? Peter Thiel-backed Compass gets FDA OK to launch Phase IIb trialsFor years now, psychedelic scientists have been telling us that tripping on magic mushrooms might “reboot” the brain, clearing out negative thought networks that might contribute to depression. Now, it ... Aug 22 18August 22, 2018Article at endpoints.news
Jaundice drug for infants rejected by FDA, shaking up Mallinckrodt's plans for newly-acquired stannsoporfinIt’s official. Mallinckrodt’s newly-acquired jaundice drug just got kicked back by the FDA. The England-based drugmaker was expecting ominous news after the agency’s advisory committee voted strongly against the drug� ... Aug 22 18August 22, 2018Article at endpoints.news
Shrink the patient group, boost the efficacy: Tonix says a retro look shows promise in select PTSD groupA backwards glance at trial data — and a reshuffling of the patients involved — has reverted failure to optimism for Tonix Pharmaceuticals. At least that’s what company execs are rooting for ... Aug 21 18August 21, 2018Article at endpoints.news
A knockdown-and-replace gene therapy from Penn researchers shows promise in rare eye diseaseIt’s been a year of great strides in gene therapy, with Spark’s Luxturna earning the first US regulatory approval in the field for inherited blindness. Now, researchers at University of ... Aug 21 18August 21, 2018Article at endpoints.news
Novo's new trial results stoke blockbuster hopes, with oral semaglutide scoring again in Phase IIIaNovo Nordisk is building a blockbuster case for its diabetes drug semaglutide, trotting out Phase IIIa trial results Monday that show its new pill version of the drug worked better ... Aug 20 18August 20, 2018Article at endpoints.news
Housing AstraZeneca's old R&D efforts in antibiotics, Entasis files for $86M IPOWhen AstraZeneca spun out its struggling antibiotics unit a few years back, the tech — and a much smaller team — was deposited into a company called Entasis. Now, that upstart has ... Aug 20 18August 20, 2018Article at endpoints.news
Outspoken researcher Peter Bach urges CMS to consider ways of bringing down CAR-T prices — and offers a few suggestionsWhen it comes to determining coverage for expensive — but potentially lifesaving — CAR-T therapies, CMS doesn’t have to roll over and let drugmakers dominate the conversation. The agency, instead, should leverage ... Aug 17 18August 17, 2018Article at endpoints.news
Months after teaming up on RTK inhibitor Lenvima, Eisai/Merck win new FDA OK in liver cancerEisai’s star cancer drug Lenvima — the subject of a recent $300 million pact with Merck — just got the green light from regulators to treat a new indication in liver cancer ... Aug 16 18August 16, 2018Article at endpoints.news
'Gap years' are for adults, too: Ex-Foundation exec Steve Kafka joins Third Rock after globetrotting breakAfter taking off the past 7 months to travel the world and spend time with family, former Foundation Medicine exec Steve Kafka is joining the startup foundry Third Rock Venture ... Aug 16 18August 16, 2018Article at endpoints.news
Armored CAR-Ts? Memorial Sloan Kettering engineers CAR-T loaded with checkpoint inhibitorsScientists at Memorial Sloan Kettering have engineered a hybrid cancer therapy that might just bring two of hottest areas of oncology science together in one package: CAR-T and checkpoint inhibitors ... Aug 15 18August 15, 2018Article at endpoints.news
Eyes on China stocks: Loncar loads new ETF with his picks for most promising biotechs on HKEX and NasdaqAn investor group based in the Midwest is tapping the booming biotech scene in China to launch a new investment vehicle for traders interested in promising Chinese ventures. Loncar Investments ... Aug 15 18August 15, 2018Article at endpoints.news
Billionaire-backed Juvenescence spins out anti-aging, AI startup Napa TherapeuticsThe billionaire-backed startup Juvenescence — best known for its big plans to tackle aging — is spinning out a new company to develop research out of the Buck Institute for Research ... Aug 14 18August 14, 2018Article at endpoints.news
Ex-Pfizer exec Geno Germano joins nanoparticle startup Elucida Oncology as CEOAfter walking away from a long career in Big Pharma last year — only to bail from his startup of choice only 10 months later — ex-Pfizer exec Geno Germano is back ... Aug 14 18August 14, 2018Article at endpoints.news
Pfizer Oncology loses its CMO to Allergan as cancer exec Charles Hugh-Jones makes a career leapAllergan {$AGN} has recruited top cancer executive Charles Hugh-Jones, the guy who’s been leading Pfizer Oncology as CMO, to serve as the pharma giant’s new senior vice president and chief ... Aug 13 18August 13, 2018Article at endpoints.news
After insider trading scandal, US congressman drops campaign — but stays on the ballot; Junshi Biosciences applies for Hong Kong IPO→ The US congressman who was charged with insider trading on a biotech stock last week has suspended his campaign for re-election. New York GOP Rep. Chris Collins, the first ... Aug 13 18August 13, 2018Article at endpoints.news
Back to the beginning: Pfizer seeds discovery-stage neuro startup Magnolia (after axing its own brain R&D)After yanking its own neuroscience efforts — and retreating from the failure-strewn battleground of brain science — Pfizer is pedaling back to the beginning in this field. The pharma giant is funding ... Aug 13 18August 13, 2018Article at endpoints.news
After mixed pipeline updates, RegenXBio to raise $175M in offering; BioElectron closes $40M to prep late-stage mitochondrial drug→ Just a couple days after announcing some mixed pipeline updates that yo-yoed the stock, gene therapy company RegenXBio {$RGNX} is trotting out news of a stock offering totaling ... Aug 10 18August 10, 2018Article at endpoints.news